(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Base Information

Chemical Name:(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester
CAS No.:866327-29-9
Molecular Formula:C₃₆H₃₉NO₅Si
Molecular Weight:593.795
Hs Code.:

Synonyms:(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

There total 4 articles about (2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13500-53-3
N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester

: 58479-61-1
tert-butylchlorodiphenylsilane

: 866327-29-9
(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ol051569d

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 866327-29-9
(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 17 h / 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; sodium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1259527

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 866327-29-9
(2S,4R)-4-(tert-butyldiphenylsiloxy)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; sodium hydrogencarbonate; In N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1259527