Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester
• CAS No.: 124909-97-3
• Molecular Formula: C₂₆H₂₄O₁₀S
• Molecular Weight: 528.537
• Mol file: 124909-97-3.mol

Synonyms:Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester

Chemical Property of Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester

There total 5 articles about Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3,6,7-trimethoxy-4-oxo-4H-chromen-5-yl ester (124909-90-6) → Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester (124909-97-3)

Guidance literature:

With aluminum tri-bromide; In acetonitrile; for 1h; Ambient temperature;

Reference yield:

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone (14639-73-7) → Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester (124909-97-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) potassium benzoate, 2.) K₂CO₃ / 1.) 170/180 deg C, 8 h, 2.) acetone, reflux, 2.5-4 h

2: 95 percent / AlBr₃ / acetonitrile / 0.33 h / 0 - 5 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 91 percent / AlBr₃ / acetonitrile / 1 h / Ambient temperature

With aluminum tri-bromide; Potassium benzoate; potassium carbonate; In acetone; acetonitrile;

Reference yield:

3,4-dimethoxybenzoic anhydride (24824-54-2) → Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester (124909-97-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) potassium benzoate, 2.) K₂CO₃ / 1.) 170/180 deg C, 8 h, 2.) acetone, reflux, 2.5-4 h

2: 95 percent / AlBr₃ / acetonitrile / 0.33 h / 0 - 5 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 91 percent / AlBr₃ / acetonitrile / 1 h / Ambient temperature

With aluminum tri-bromide; Potassium benzoate; potassium carbonate; In acetone; acetonitrile;

upstream raw materials:

Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3,6,7-trimethoxy-4-oxo-4H-chromen-5-yl ester

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone

3,4-dimethoxybenzoic anhydride

3,5,6,7,3',4'-Hexamethoxyflavon

Downstream raw materials:

3,5-dihydroxy-6,7,3′,4′-tetramethoxyflavone

Acetic acid 3-acetoxy-2-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester