Technology Process of N-(5-tetrazolyl)-4-methyl-6-(4-dimethylaminophenyl)-2-pyridinecarboxamide
There total 10 articles about N-(5-tetrazolyl)-4-methyl-6-(4-dimethylaminophenyl)-2-pyridinecarboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 30percent aq. H2O2 / acetic acid / 20 h / 80 °C
2: 1.) Me2SO4 / 1.) 80-90 deg C, 2 h, 2.) dioxane, H2O, RT, 30 min
3: 5 M aq. HCl / 11 h / Heating
4: H2, AcONa / 10percent Pd/C / dimethylformamide
5: SOCl2 / 4 h / Heating
6: 69.6 percent / K2CO3 / dimethylformamide / a) 50 deg C, 0.5 h, b) 100 deg C, 3 h
7: 8percent aq. HCl / 5 h / 80 °C
8: dimethylformamide / 1 h / Ambient temperature
9: dimethylformamide / 2 h / 60 - 70 °C
With
hydrogenchloride; thionyl chloride; hydrogen; dihydrogen peroxide; sodium acetate; potassium carbonate; dimethyl sulfate;
palladium on activated charcoal;
In
acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 5 M aq. HCl / 11 h / Heating
2: H2, AcONa / 10percent Pd/C / dimethylformamide
3: SOCl2 / 4 h / Heating
4: 69.6 percent / K2CO3 / dimethylformamide / a) 50 deg C, 0.5 h, b) 100 deg C, 3 h
5: 8percent aq. HCl / 5 h / 80 °C
6: dimethylformamide / 1 h / Ambient temperature
7: dimethylformamide / 2 h / 60 - 70 °C
With
hydrogenchloride; thionyl chloride; hydrogen; sodium acetate; potassium carbonate;
palladium on activated charcoal;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) Me2SO4 / 1.) 80-90 deg C, 2 h, 2.) dioxane, H2O, RT, 30 min
2: 5 M aq. HCl / 11 h / Heating
3: H2, AcONa / 10percent Pd/C / dimethylformamide
4: SOCl2 / 4 h / Heating
5: 69.6 percent / K2CO3 / dimethylformamide / a) 50 deg C, 0.5 h, b) 100 deg C, 3 h
6: 8percent aq. HCl / 5 h / 80 °C
7: dimethylformamide / 1 h / Ambient temperature
8: dimethylformamide / 2 h / 60 - 70 °C
With
hydrogenchloride; thionyl chloride; hydrogen; sodium acetate; potassium carbonate; dimethyl sulfate;
palladium on activated charcoal;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026
