Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Chemical Name:Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate
CAS No.:144750-91-4
Molecular Formula:C₂₂H₂₅N₅O₆
Molecular Weight:455.47
Hs Code.:

Synonyms:Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Chemical Property of Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Technology Process of Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

There total 4 articles about Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 144750-88-9
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

: 144750-91-4
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In trifluoroacetic acid; under 2585.7 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)80479-8

Reference yield:

: 144750-84-5
2-Methyl-5-bromo-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidine

: 144750-91-4
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / NEt₃, CuI / Pd(PPh₃)4 / dimethylformamide / 3 h / 105 °C

2: 41 percent / H₂ / 10percent Pd-C / trifluoroacetic acid / 2585.7 Torr / Ambient temperature

With copper(l) iodide; hydrogen; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)80479-8

Reference yield:

: 135352-72-6
Dimethyl N-(4-ethynylbenzoyl)-L-glutamate

: 144750-91-4
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / NEt₃, CuI / Pd(PPh₃)4 / dimethylformamide / 3 h / 105 °C

2: 41 percent / H₂ / 10percent Pd-C / trifluoroacetic acid / 2585.7 Torr / Ambient temperature

With copper(l) iodide; hydrogen; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)80479-8