(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

Base Information

Chemical Name:(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol
CAS No.:352238-75-6
Molecular Formula:C₂₆H₂₅NO₅
Molecular Weight:431.488
Hs Code.:

Synonyms:(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

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Chemical Property of (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

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Technology Process of (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

There total 3 articles about (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 15248-39-2
6,7-dimethoxyisoquinoline

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 352238-75-6
(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

Guidance literature:: 6,7-dimethoxyisoquinoline; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 4h; Inert atmosphere; Schlenk technique;

3-benzyloxy-4-methoxybenzaldehyde; In tetrahydrofuran; at 0 - 25 ℃; for 16h; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1039/c5ob00926j

Reference yield: 32.0%

: 50299-95-1,35096-40-3
2-benzoyl-1-cyano-6,7-dimethoxy-1,2-dihydroisoquinoline

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 352238-75-6
(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

Guidance literature:: 2-benzoyl-1-cyano-6,7-dimethoxy-1,2-dihydroisoquinoline; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃; for 0.0833333h;

3-benzyloxy-4-methoxybenzaldehyde; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

With potassium hydroxide; In ethanol; for 3h; Further stages.; Heating;
DOI:10.1021/np0101200

Reference yield:

: 15248-39-2
6,7-dimethoxyisoquinoline

: 352238-75-6
(±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 42 percent / CH₂Cl₂ / 5 h / 20 °C

2.1: NaH / dimethylformamide / 0.08 h / -10 °C

2.2: dimethylformamide / 4 h / 0 - 20 °C

2.3: 32 percent / aq. KOH / ethanol / 3 h / Heating

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/np0101200