3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

Base Information

Chemical Name:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt
CAS No.:1035155-15-7
Molecular Formula:C₂HF₃O₂*C₂₃H₂₉F₂NO₃
Molecular Weight:519.509
Hs Code.:

Synonyms:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

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Chemical Property of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

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Technology Process of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

There total 15 articles about 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1035155-06-6
ethyl 3-[3,4-difluoro-5-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

: 58518-92-6
1,1-dimethyl-4-phenyl-butylamine

: 76-05-1
trifluoroacetic acid

: 1035155-15-7
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

Guidance literature:: ethyl 3-[3,4-difluoro-5-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate; 1,1-dimethyl-4-phenyl-butylamine; In ethanol; at 90 ℃; for 22h;

With sodium hydroxide; In ethanol; water; at 20 ℃; for 24h;

trifluoroacetic acid; In ethanol; water; HPLC;

Reference yield:

: 5-bromo-2,3-difluoro-phenol

: 1035155-15-7
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tri-p-tolylphosphite / propiononitrile / 120 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 20 °C

3.2: 2 h

4.1: AD-mix-α / water; tert-butyl alcohol / 6 h / 0 - 20 °C

5.1: pyridine / -15 - 0 °C

6.1: ethanol / 22 h / 90 °C

6.2: 24 h / 20 °C

6.3: HPLC

With pyridine; AD-mix-α; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium diacetate; bis(tributylphosphine) palladium; tri-p-tolylphosphite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; propiononitrile; tert-butyl alcohol; 3.1: Stille Reaction;

Reference yield:

: 1035154-98-3
ethyl 3-(3,4-difluoro-5-hydroxyphenyl)propanoate

: 1035155-15-7
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

2.2: 2 h / 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: pyridine / 4.62 h / -20 - -10 °C

5.1: ethanol / 22 h / 90 °C

5.2: 24 h / 20 °C

5.3: HPLC

With pyridine; AD-mix-α; triethylamine; lithium chloride; bis(tributylphosphine) palladium; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2.1: Curtius Rearrangement;