3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine

Base Information

• Chemical Name: 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine
• CAS No.: 80971-35-3
• Molecular Formula: C₃₇H₄₇N₃O₆Si
• Molecular Weight: 657.882
• Mol file: 80971-35-3.mol

Synonyms:3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine

Chemical Property of 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine

There total 1 articles about 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside (80971-34-2) → 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine (80971-35-3)

Guidance literature:

With ammonia; water; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1093/nar/gkq855

Reference yield:

3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine (80971-35-3) → C50H63N6O13PSi

Guidance literature:

Multi-step reaction with 3 steps

1: water; acetic acid / 3.5 h

2: benzimidazolium trifluoromethanesulfonate / acetonitrile / 5 h / 20 °C

3: pyridine; water; iodine / tetrahydrofuran / 1 h

With pyridine; water; iodine; acetic acid; benzimidazolium trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile;

DOI:10.1093/nar/gkq855

Reference yield:

3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine (80971-35-3) → C50H63N6O12PSi

Guidance literature:

Multi-step reaction with 2 steps

1: water; acetic acid / 3.5 h

2: benzimidazolium trifluoromethanesulfonate / acetonitrile / 5 h / 20 °C

With water; acetic acid; benzimidazolium trifluoromethanesulfonate; In acetonitrile;

DOI:10.1093/nar/gkq855

upstream raw materials:

3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside