(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

Base Information

Chemical Name:(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol
CAS No.:1027885-23-9
Molecular Formula:C₁₁H₁₁Cl₂N₃O₂
Molecular Weight:288.133
Hs Code.:

Synonyms:(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

Chemical Property:

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Technology Process of (S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

There total 4 articles about (S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

: 1027885-23-9
(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm990229t

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 1027885-23-9
(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; aq. NaOH / ethanol / 48 h / Heating

2: EDC*HCl; HOBT; diisopropylethylamine / dimethylformamide / 15 h / 20 °C

3: pyridine / 0.5 h / Heating

4: aq. TFA / CH₂Cl₂ / 3 h / 20 °C

With pyridine; sodium hydroxide; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Hydroxyamination / 2: Acylation / 3: Condensation; Cyclization / 4: Deprotection;
DOI:10.1021/jm990229t

Reference yield:

: 925252-75-1,176860-57-4
2-(3,4-dichlorophenyl)-N-hydroxyethanimidamide

: 1027885-23-9
(S)-2-Amino-2-[3-(3,4-dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: EDC*HCl; HOBT; diisopropylethylamine / dimethylformamide / 15 h / 20 °C

2: pyridine / 0.5 h / Heating

3: aq. TFA / CH₂Cl₂ / 3 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation; Cyclization / 3: Deprotection;
DOI:10.1021/jm990229t