4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

Base Information

Chemical Name:4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine
CAS No.:1027409-06-8
Molecular Formula:C₃₆H₅₅NO₂Si₂
Molecular Weight:590.009
Hs Code.:

4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

Synonyms:4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

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Chemical Property of 4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

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Technology Process of 4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

There total 8 articles about 4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1027508-87-7
4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-cyclohexylmethyl}-piperidin-4-ol

: 4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-2-enylmethyl}-1,2,3,6-tetrahydro-pyridine

: 1027409-06-8
4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 1027409-06-8
4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) s-BuLi / 1.) cyclohexane, THF, -78 deg C, 30 min, 2.) cyclohexane, THF, -78 deg C, 2 h

2: 30 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C

With sec.-butyllithium; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1027409-06-8
4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-{(R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enylmethyl}-1,2,3,6-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 41.0 g / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CH₂Cl₂ / 25 °C

2: 63 percent / CH₃SO₃H / CH₂Cl₂ / 25 °C

3: AlCl₃, LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4: conc. HCl / 2 h / Heating

5: 1.) s-BuLi / 1.) cyclohexane, THF, -78 deg C, 30 min, 2.) cyclohexane, THF, -78 deg C, 2 h

6: 30 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; methanesulfonic acid; sec.-butyllithium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;