(2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone

Base Information

• Chemical Name: (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone
• CAS No.: 191528-62-8
• Molecular Formula: C₁₃H₁₆N₄O₂
• Molecular Weight: 260.296
• Mol file: 191528-62-8.mol

Synonyms:(2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone

Chemical Property of (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone

There total 15 articles about (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Carbonic acid 2-[(S)-1-(2-azido-benzoyl)-pyrrolidin-2-yl]-ethyl ester methyl ester (191528-61-7) → (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone (191528-62-8)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1016/S0040-4039(97)00680-1

Reference yield:

(-)-(S)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylic acid benzyl ester (143771-06-6) → (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone (191528-62-8)

Guidance literature:

Multi-step reaction with 4 steps

2: H₂ / Pd/C / methanol

4: 91 percent / K₂CO₃ / methanol

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(97)00680-1

Reference yield:

(-)-(S)-2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid benzyl ester (56633-72-8) → (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone (191528-62-8)

Guidance literature:

Multi-step reaction with 6 steps

1: LiOH / dioxane

2: BH₃*THF

4: H₂ / Pd/C / methanol

6: 91 percent / K₂CO₃ / methanol

With lithium hydroxide; borane-THF; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4039(97)00680-1

upstream raw materials:

Carbonic acid 2-[(S)-1-(2-azido-benzoyl)-pyrrolidin-2-yl]-ethyl ester methyl ester

1-(tert-butoxycarbonyl)-L-proline

2-azidobenzoic acid

o-azidobenzoyl chloride

Downstream raw materials:

[(S)-1-(2-Azido-benzoyl)-pyrrolidin-2-yl]-acetaldehyde