4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

Base Information

Chemical Name:4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin
CAS No.:1259500-83-8
Molecular Formula:C₅₃H₇₈ClN₅O₁₅
Molecular Weight:1060.68
Hs Code.:

Synonyms:4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

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Chemical Property of 4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

Chemical Property:

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Technology Process of 4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

There total 6 articles about 4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₅H₈₀ClN₅O₁₆

: 1259500-83-8
4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

Guidance literature:: With methanol; at 75 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.04.004

Reference yield:

: 103461-66-1
2'-O-acetyl-6-O-methylerythromycin A

: 1259500-83-8
4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / toluene / 12 h / 65 °C

2.1: hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 7 h / 20 °C

3.1: tetrahydrofuran / 20 °C

3.2: Saturated solution

4.1: methanol / 8 h / 75 °C

With methanol; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2011.04.004

Reference yield:

: 81103-11-9
clarithromycin

: 1259500-83-8
4''-O-(2-(4-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 24 h / 20 °C

2.1: triethylamine / toluene / 12 h / 65 °C

3.1: hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 7 h / 20 °C

4.1: tetrahydrofuran / 20 °C

4.2: Saturated solution

5.1: methanol / 8 h / 75 °C

With methanol; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2011.04.004