(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

Base Information

Chemical Name:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate
CAS No.:1079392-86-1
Molecular Formula:C₂₆H₂₁F₅N₂O₃
Molecular Weight:504.456
Hs Code.:

Synonyms:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

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Chemical Property of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

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Technology Process of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

There total 4 articles about (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1079392-93-0
C₃₅H₄₁F₅N₂O₃Si

: 1079392-86-1
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; at 0 ℃; for 0.166667h;
DOI:10.1039/b807640e

Reference yield:

: 130-95-0
Quinine

: 1079392-86-1
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium thioethylate / N,N-dimethyl-formamide / 24 h / 105 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: pyridine; hydrogen fluoride / acetonitrile / 0.5 h / 0 °C

With pyridine; 1H-imidazole; hydrogen fluoride; triethylamine; sodium thioethylate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/adsc.201701224

Reference yield:

: 524-63-0,70877-75-7
4-[(R)-((2S,4S,5R)-5-ethenyl-1-azabicyclo-[2.2.2]octan-2-yl)(hydroxy)methyl]quinolin-6-ol

: 1079392-86-1
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 2,3,4,5,6-pentafluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: pyridine; hydrogen fluoride / acetonitrile / 0.5 h / 0 °C

With pyridine; 1H-imidazole; hydrogen fluoride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/adsc.201701224