C₂₀H₂₆ClNO₃

Base Information

• Chemical Name: C₂₀H₂₆ClNO₃
• CAS No.: 1009376-46-8
• Molecular Formula: C₂₀H₂₆ClNO₃
• Molecular Weight: 363.884
• Mol file: 1009376-46-8.mol

Synonyms:C₂₀H₂₆ClNO₃

Chemical Property of C₂₀H₂₆ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₀H₂₆ClNO₃

There total 1 articles about C₂₀H₂₆ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

methyl-2 nipecotate d'ethyle (90950-34-8) + 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid (50921-39-6) → C20H26ClNO3 (1009376-46-8)

Guidance literature:

With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 22.5%

C20H26ClNO3 (1009376-46-8) → C18H26ClNO (908244-95-1)

Guidance literature:

C₂₀H₂₆ClNO₃; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With water; In tetrahydrofuran; at 0 ℃;

Reference yield: 22.5%

C20H26ClNO3 (1009376-46-8) → C18H24ClNO2

Guidance literature:

C₂₀H₂₆ClNO₃; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With sulfuric acid; water; In tetrahydrofuran; at 0 ℃; pH=3.3; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; water; pH=8.0; Inert atmosphere;

upstream raw materials:

methyl-2 nipecotate d'ethyle

1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

Downstream raw materials:

C₁₈H₂₆ClNO

Refernces

• 1、 -. "DOPAMINE TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF MOVEMENT DISORDERS AND OTHER CNS INDICATIONS". Page/Page column 25. . Retrieved 2008/06/13.