8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Base Information

Chemical Name:8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine
CAS No.:717876-69-2
Molecular Formula:C₄₀H₄₉N₅O₄Si₂
Molecular Weight:720.031
Hs Code.:

Synonyms:8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

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Chemical Property of 8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

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Technology Process of 8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

There total 1 articles about 8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 34993-56-1
1-ethynylpyrene

: 479408-21-4
3',5'-O,O'-bis(tert-butyldimethylsilyl)-8-bromo-2'-deoxyguanosine

: 717876-69-2
8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1039/b416965d

Reference yield:

: 717876-69-2
8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 2-N-(N,N-dimethylaminomethylidenyl)-8-(1-pyrenyl)ethynyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

2: dimethylformamide / 5 h / 20 °C

3: 1.12 g / pyridine / 6 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b416965d

Reference yield:

: 717876-69-2
8-(1-pyrenyl)ethynyl-3',5'-O,O'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 2-N-(N,N-dimethylaminomethylidenyl)-8-(1-pyrenyl)ethynyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)guanosine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

2: dimethylformamide / 5 h / 20 °C

3: 1.12 g / pyridine / 6 h / 20 °C

4: 100 percent / 1H-tetrazole / acetonitrile / 1.5 h / 20 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b416965d