trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Base Information

Chemical Name:trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester
CAS No.:951655-66-6
Molecular Formula:C₂₈H₂₅NO₅S
Molecular Weight:487.576
Hs Code.:

Synonyms:trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Suppliers and Price of trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

There total 5 articles about trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 951655-64-4
3-(1-benzenesulfonyl-1H-indole-2-carbonyl)benzaldehyde

: 35000-37-4
(tert-butyloxycarbonylmethyl)triphenylphosphonium chloride

: 951655-66-6
trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; triethylamine; In dichloromethane; at 20 ℃; for 96h;
DOI:10.1021/jm0703136

Reference yield:

: 773101-97-6
3-[1,3]dioxolan-2-yl-benzoic acid

: 951655-66-6
trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 66 percent / SOCl₂; pyridine / tetrahydrofuran / 0.5 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 36 percent / hexane; tetrahydrofuran / -78 - 20 °C

3.1: 38 percent / aq. HClO₄ / CH₂Cl₂ / 0 °C

4.1: 64 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 96 h / 20 °C

With pyridine; sodium hydroxide; n-butyllithium; thionyl chloride; perchloric acid; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 4.1: Wittig olefination;
DOI:10.1021/jm0703136

Reference yield:

: 951655-57-5
3-[1,3]dioxolan-2-ylbenzoyl chloride

: 951655-66-6
trans-3-[3-(1-benzenesulfonyl-1H-indole-2-carbonyl)phenyl]acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 36 percent / hexane; tetrahydrofuran / -78 - 20 °C

2.1: 38 percent / aq. HClO₄ / CH₂Cl₂ / 0 °C

3.1: 64 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 96 h / 20 °C

With sodium hydroxide; n-butyllithium; perchloric acid; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 3.1: Wittig olefination;
DOI:10.1021/jm0703136