4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid

Base Information

• Chemical Name: 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid
• CAS No.: 159586-51-3
• Molecular Formula: C₃₀H₃₁N₅O₆
• Molecular Weight: 557.606

Synonyms:4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid

Chemical Property of 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid

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Technology Process of 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid

There total 4 articles about 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid ethyl ester → 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid (159586-51-3)

Guidance literature:

With potassium hydroxide; In methanol; water;

DOI:10.1016/S0960-894X(96)00249-1

Reference yield:

3-tolyl isocyanate (621-29-4) → 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid (159586-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: <(n-Bu)3Sn>2O

3: KOH / methanol; H₂O

With potassium hydroxide; triethylamine; bis(tri-n-butyltin)oxide; In methanol; water;

DOI:10.1016/S0960-894X(96)00249-1

Reference yield:

1,3-dihydro-1-(2-hydroxyethyl)-3-(R,S)-amino-5-phenyl-1H-1,4-benzodiazepin-2-one (136051-17-7) → 4-{2-[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethoxycarbonylamino}-butyric acid (159586-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: <(n-Bu)3Sn>2O

3: KOH / methanol; H₂O

With potassium hydroxide; triethylamine; bis(tri-n-butyltin)oxide; In methanol; water;

DOI:10.1016/S0960-894X(96)00249-1

upstream raw materials:

3-tolyl isocyanate

1,3-dihydro-1-(2-hydroxyethyl)-3-(R,S)-amino-5-phenyl-1H-1,4-benzodiazepin-2-one

(R,S)-N-(2,3-dihydro-1-(2-hydroxyethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)urea

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