C₂₁H₂₇FN₄O₄

Base Information

Chemical Name:C₂₁H₂₇FN₄O₄
CAS No.:1380494-60-9
Molecular Formula:C₂₁H₂₇FN₄O₄
Molecular Weight:418.468
Hs Code.:

C<sub>21</sub>H<sub>27</sub>FN<sub>4</sub>O<sub>4</sub>

Synonyms:C₂₁H₂₇FN₄O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₂₇FN₄O₄

Chemical Property:

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Technology Process of C₂₁H₂₇FN₄O₄

There total 12 articles about C₂₁H₂₇FN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1380494-58-5
tert-butyl 1'-(4-((S)-5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)-2-oxa-3-azaspiro[bicyclo[2.2.1]heptane-7,4'-piperidine]-3-carboxylate

: 1380494-60-9
C₂₁H₂₇FN₄O₄

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.026

Reference yield:

: 1'-benzyl 3-tert-butyl 2-oxa-3-azaspiro[bicyclo[2.2.1]hept[5]ene-7,4'-piperidine]-1',3-dicarboxylate

: 1380494-60-9
C₂₁H₂₇FN₄O₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 8 h / 20 °C / 2585.81 Torr

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

5.2: -78 - 25 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

7.1: sodium azide / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

9.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmc.2012.04.026

Reference yield:

: tert-butyl 2-oxa-3-azaspiro[bicyclo[2.2.1]heptane-7,4'-piperidine]-3-carboxylate

: 1380494-60-9
C₂₁H₂₇FN₄O₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 25 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

7.1: sodium azide / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

9.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmc.2012.04.026