(1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

Base Information

Chemical Name:(1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene
CAS No.:201472-99-3
Molecular Formula:C₁₆H₁₈FNO₂
Molecular Weight:275.323
Hs Code.:

Synonyms:(1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

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Technology Process of (1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

There total 2 articles about (1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1765-93-1
4-fluoroboronic acid

: 201472-98-2
(1S)-N-methyl-2-carbomethoxy-3-{[(trifluoromethyl)sulfonyl]oxy}-8-azabicyclo[3.2.1]-2-octene

: 201472-99-3
(1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; lithium chloride; In water; for 1h; Heating;
DOI:10.1021/jm970669p

Reference yield:

: 112652-64-9
(S)-(-)-2-(carbomethoxy)-3-tropinone

: 201472-99-3
(1S)-N-methyl-2-carbomethoxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]-2-octene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 0.5 h, 2.) THF, from -78 to 5 deg C, 38 h

2: 86 percent / LiCl, tris(dibenzylideneacetone)dipalladium⁽⁰⁾, Na₂CO₃ / H₂O; various solvent(s) / 1 h / Heating

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hexamethyldisilazide; sodium carbonate; lithium chloride; In water;
DOI:10.1021/jm970669p