1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane

Base Information

• Chemical Name: 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane
• CAS No.: 916330-70-6
• Molecular Formula: C₅₂H₄₆O₁₃
• Molecular Weight: 878.929
• Mol file: 916330-70-6.mol

Synonyms:1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane

Chemical Property of 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane

There total 7 articles about 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5-(benzyloxy)-2-(4-hydroxyphenyl)-7-(methoxymethoxy)-4H-chromen-4-one (916330-61-5) + diethylene glycol ditosylate (7460-82-4) → 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane (916330-70-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1021/jm060593+

Reference yield: 40.0%

→ 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane (916330-70-6)

Guidance literature:

Reference yield:

5-hydroxy-7-methoxymethoxy-2-(4-allyloxyphenyl)-4H-chromen-4-one (916330-66-0) → 1,7-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7-trioxaheptane (916330-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 78 percent / Pd(PPh₃)4; K₂CO₃ / methanol / 2 h / Heating

3: 40 percent / K₂CO₃ / dimethylformamide / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060593+

upstream raw materials:

5-(benzyloxy)-2-(4-hydroxyphenyl)-7-(methoxymethoxy)-4H-chromen-4-one

diethylene glycol ditosylate

5-hydroxy-7-methoxymethoxy-2-(4-allyloxyphenyl)-4H-chromen-4-one

trans-3-(4-allyloxyphenyl)-1-[2,4-bis(methoxymethoxy)-6-hydroxyphenyl]prop-2-en-1-one