2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

Base Information

Chemical Name:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine
CAS No.:1310532-34-3
Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Hs Code.:

Synonyms:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

Chemical Property:

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Technology Process of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

There total 5 articles about 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1310532-33-2
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]benzonitrile

: 1310532-34-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

Guidance literature:: With hydroxylamine; In ethanol; water; at 20 - 80 ℃;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310532-34-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 16 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3: zinc; ammonium formate / ethanol / 2 h / 50 °C

4: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

5: hydroxylamine / ethanol; water / 20 - 80 °C

With Oxone; hydroxylamine; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310532-34-3
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxybenzamidine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2: zinc; ammonium formate / ethanol / 2 h / 50 °C

3: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

4: hydroxylamine / ethanol; water / 20 - 80 °C

With Oxone; hydroxylamine; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;