cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

Base Information

Chemical Name:cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol
CAS No.:1315489-74-7
Molecular Formula:C₁₅H₁₈N₄O
Molecular Weight:270.334
Hs Code.:

Synonyms:cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

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Chemical Property of cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

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Technology Process of cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

There total 6 articles about cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6850-39-1,6982-42-9,40525-77-7
(+/-)-cis-3-aminocyclohexanol

: 1315489-74-7
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

: 1315489-73-6
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 3 h / 65 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / 18 h / 25 °C / 5171.62 Torr

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

3.2: 2 h / 70 °C / Inert atmosphere

4.1: water; sodium hydroxide / ethanol / 18 h / 50 °C / Inert atmosphere

With palladium 10% on activated carbon; triethyloxonium tetrafluoroborate; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm300628c

Reference yield:

: C₂₁H₂₂N₄O₃S

: 1315489-74-7
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

: 1315489-73-6
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

Guidance literature:: With water; sodium hydroxide; In ethanol; at 50 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm300628c

Reference yield:

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1315489-74-7
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

: 1315489-73-6
cis-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 3 h / 65 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / 18 h / 25 °C / 5171.62 Torr

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

3.2: 2 h / 70 °C / Inert atmosphere

4.1: water; sodium hydroxide / ethanol / 18 h / 50 °C / Inert atmosphere

With palladium 10% on activated carbon; triethyloxonium tetrafluoroborate; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm300628c