methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

Base Information

Chemical Name:methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate
CAS No.:222054-82-2
Molecular Formula:C₅₂H₆₅N₃O₁₂
Molecular Weight:924.101
Hs Code.:

Synonyms:methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

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Chemical Property of methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

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Technology Process of methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

There total 3 articles about methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 129716-58-1,153653-31-7
5-[3-(4-(2,2-diphenylacetyl)piperazine-1-yl)-2-hydroxypropoxy]quinoline

: 201789-50-6
(2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)

: 222054-83-3
methyl 1-O-<(S)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

: 222054-82-2
methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

Guidance literature:: With boron trifluoride diethyl etherate; In nitromethane; chloroform; for 4h; Ambient temperature;
DOI:10.1016/S0960-894X(99)00056-6

Reference yield:

: 86448-92-2
methyl 1-bromo-1-desoxy-O²,O³,O⁴-tri(2,2-dimethyl-1-oxopropyl)-α-D-glucuronate

: 222054-82-2
methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

Guidance literature:: Multi-step reaction with 3 steps

1: Ag₂CO₃, AgOTf, H₂O / acetone; H₂O

2: DBU / CH₂Cl₂

3: 13 percent / BF₃*Et₂O / CHCl₃; nitromethane / 4 h / Ambient temperature

With boron trifluoride diethyl etherate; water; silver trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; silver carbonate; In nitromethane; dichloromethane; chloroform; water; acetone;
DOI:10.1016/S0960-894X(99)00056-6

Reference yield:

: 86448-97-7,86448-98-8
methyl 2,3,4-tri-O-pivaloyl-α,β-D-glucopyranuronate

: 222054-82-2
methyl 1-O-<(R)-3-<4-(2,2-diphenylacetyl)piperazin-1-yl>-1-(quinolin-5-yloxy)-2-propyl>-2,3,4-tri-O-pivaloyl-β-D-glucuronate

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / CH₂Cl₂

2: 13 percent / BF₃*Et₂O / CHCl₃; nitromethane / 4 h / Ambient temperature

With boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In nitromethane; dichloromethane; chloroform;
DOI:10.1016/S0960-894X(99)00056-6