(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

Base Information

Chemical Name:(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane
CAS No.:108868-57-1
Molecular Formula:C₂₀H₃₈N₂O₄
Molecular Weight:370.533
Hs Code.:

Synonyms:(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

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Technology Process of (2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

There total 1 articles about (2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108868-91-3
(2S,3S)-1-amino-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane acetic acid salt

: 108-12-3
isopentanoyl chloride

: 108868-57-1
(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm00390a018

Reference yield:

: 108868-57-1
(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

: N-((2S,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-3-methyl-butyramide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1021/jm00390a018

Reference yield:

: 108868-57-1
(2S,3S)-1-<<(2-methylpropyl)carbonyl>amino>-2-hydroxy-3-<(tert-butyloxycarbonyl)amino>-4-cyclohexylbutane

: 108868-65-1
{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(3-methyl-butyrylamino)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4 M aq. HCl / dioxane

2: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018