N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

Base Information

Chemical Name:N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide
CAS No.:1365957-90-9
Molecular Formula:C₂₉H₂₀N₂O₄S
Molecular Weight:492.555
Hs Code.:

Synonyms:N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

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Technology Process of N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

There total 5 articles about N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1365958-75-3
N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

: 1365957-90-9
N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

Guidance literature:: With boron tribromide; In dichloromethane; at -25 - 20 ℃; for 4h;
DOI:10.1021/jm201735j

Reference yield:

: 1365958-40-2
2-(benzyloxy)-6-(3-(benzyloxy)phenyl)-1-bromonaphthalene

: 1365957-90-9
N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.25 h / 150 °C / 1125.11 Torr / Microwave irradiation

2: pyridine; dmap / 144 h / 20 °C

3: boron tribromide / dichloromethane / 4 h / -25 - 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; caesium carbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1021/jm201735j

Reference yield:

: 16239-18-2
1,6-dibromo-2-naphthol

: 1365957-90-9
N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol / 15 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / tetrahydrofuran; water / 4 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.25 h / 150 °C / 1125.11 Torr / Microwave irradiation

4: pyridine; dmap / 144 h / 20 °C

5: boron tribromide / dichloromethane / 4 h / -25 - 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1021/jm201735j