Technology Process of (2R,3S)-1-(3-phenyl-1, 1-dioxo-tetrahydrothiophen-2-yl)ethanone
There total 6 articles about (2R,3S)-1-(3-phenyl-1, 1-dioxo-tetrahydrothiophen-2-yl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); copper(l) chloride;
In
dichloromethane;
for 3h;
optical yield given as %ee;
enantioselective reaction;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water; ethanol / 3 h / Reflux
2.1: lithium aluminium tetrahydride / diethyl ether / 21 h / Reflux
3.1: potassium carbonate / acetone / 0.25 h
3.2: 18 h / Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
5.1: potassium carbonate; 4-toluenesulfonyl azide / acetonitrile / 3.5 h / 0 - 20 °C / Inert atmosphere
6.1: copper(l) chloride; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole) / dichloromethane / 26 h / Inert atmosphere; Reflux
With
lithium aluminium tetrahydride; 4-toluenesulfonyl azide; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; potassium carbonate; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole); 3-chloro-benzenecarboperoxoic acid; copper(l) chloride;
In
diethyl ether; ethanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/ejoc.201800077
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
2: potassium carbonate; 4-toluenesulfonyl azide / acetonitrile / 3.5 h / 0 - 20 °C / Inert atmosphere
3: copper(l) chloride; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole) / dichloromethane / 26 h / Inert atmosphere; Reflux
With
4-toluenesulfonyl azide; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; potassium carbonate; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole); 3-chloro-benzenecarboperoxoic acid; copper(l) chloride;
In
dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201800077
