N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

Base Information

Chemical Name:N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole
CAS No.:138384-53-9
Molecular Formula:C₂₅H₂₂N₄O₂S
Molecular Weight:442.541
Hs Code.:

N<sup>6</sup>-<4-(phenylsulfonyl)benzyl>-N<sup>6</sup>-methyl-6-amino-2-hydrazinobenz<cd>indole

Synonyms:N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

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Technology Process of N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

There total 12 articles about N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 138385-05-4
N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-2-(methylthio)-6-aminobenzindole

: 138384-53-9
N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

Guidance literature:: With hydrazine; In methanol; at 130 ℃; for 2.5h;
DOI:10.1021/jm00082a006

Reference yield:

: 130-00-7
1,8-naphtholactam

: 138384-53-9
N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / 70percent HNO₃ / acetic acid / 1 h / 20 - 50 °C

2: H₂ / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr

3: 71 percent / DIEA / dimethylformamide / 3 h / 75 °C

4: 26 percent / DIEA / dimethylformamide / 19 h / 95 °C

5: 47 percent / Lawesson's reagent / toluene / 1 h / 120 °C

6: 95 percent / 1 N NaOH / aq. ethanol; tetrahydrofuran / 0.5 h / 25 °C

7: 87 percent / N₂H₄ / methanol / 2.5 h / 130 °C

With Lawessons reagent; sodium hydroxide; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; hydrazine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00082a006

Reference yield:

: 28434-96-0
N-hydroxy-4-nitro-1,8-naphthalimide

: 138384-53-9
N⁶-<4-(phenylsulfonyl)benzyl>-N⁶-methyl-6-amino-2-hydrazinobenzindole

Guidance literature:: Multi-step reaction with 8 steps

1: Na₂CO₃ / H₂O / 1 h / Heating

2: NaOH / ethanol; H₂O / 16 h / 25 °C

3: H₂ / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr

4: 71 percent / DIEA / dimethylformamide / 3 h / 75 °C

5: 26 percent / DIEA / dimethylformamide / 19 h / 95 °C

6: 47 percent / Lawesson's reagent / toluene / 1 h / 120 °C

7: 95 percent / 1 N NaOH / aq. ethanol; tetrahydrofuran / 0.5 h / 25 °C

8: 87 percent / N₂H₄ / methanol / 2.5 h / 130 °C

With Lawessons reagent; sodium hydroxide; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00082a006