C₂₇H₃₆O₃Si

Base Information

• Chemical Name: C₂₇H₃₆O₃Si
• CAS No.: 1324006-25-8
• Molecular Formula: C₂₇H₃₆O₃Si
• Molecular Weight: 436.667
• Mol file: 1324006-25-8.mol

Synonyms:C₂₇H₃₆O₃Si

Chemical Property of C₂₇H₃₆O₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₆O₃Si

There total 4 articles about C₂₇H₃₆O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butylchlorodiphenylsilane (58479-61-1) + (4S,6R,7R)-6,7-di-O-isopropylideneoct-1-yn-4-ol (111043-64-2) → C27H36O3Si (1324006-25-8)

Guidance literature:

With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja205673e

Reference yield:

C8H13NO2 (1324006-24-7) → C27H36O3Si (1324006-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether; hexane / 2 h / -78 - 0 °C / Inert atmosphere

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / tetrahydrofuran; toluene / 1 h / -10 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

3.1: 1H-imidazole; dmap / dichloromethane / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; chloro-trimethyl-silane; diisobutylaluminium hydride; ethylene dibromide; zinc; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1021/ja205673e

Reference yield:

(+)-(3R,4R)-3,4-dihydroxypentanenitrile (1324006-23-6) → C27H36O3Si (1324006-25-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 25 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / diethyl ether; hexane / 2 h / -78 - 0 °C / Inert atmosphere

3.1: chloro-trimethyl-silane; ethylene dibromide; zinc / tetrahydrofuran; toluene / 1 h / -10 °C / Inert atmosphere

3.2: -78 - 0 °C / Inert atmosphere

4.1: 1H-imidazole; dmap / dichloromethane / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; chloro-trimethyl-silane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; ethylene dibromide; zinc; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1021/ja205673e

upstream raw materials:

(+)-(3R,4R)-3,4-dihydroxypentanenitrile

C₈H₁₃NO₂

3-pentenenitrile

tert-butylchlorodiphenylsilane