acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

Base Information

Chemical Name:acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester
CAS No.:493021-05-9
Molecular Formula:C₂₉H₃₆O₄Si
Molecular Weight:476.688
Hs Code.:

acetic acid 3-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1<i>H</i>-inden-5-yl ester

Synonyms:acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

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Chemical Property of acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

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Technology Process of acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

There total 9 articles about acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 546-67-8
lead(IV) tetraacetate

: 493021-04-8
(1S,7aR)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one

: acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

: 493021-05-9
acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

Guidance literature:: In toluene; at 138 ℃;
DOI:10.1021/ol027125o

Reference yield:

: 17553-86-5
(S)-Halos-Parish ketone

: 493021-05-9
acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / sodium borohydride / ethanol / 4 h / -15 °C

2: 93 percent / pyridine; 4-(dimethylamino)pyridine / 0 - 20 °C

3: 85 percent / dimethylsulfoxide / 3 h / 20 °C

4: 95 percent / pTSA / benzene / 5 h / Heating

5: 91 percent / diisobutylaluminum hydride / toluene / 1 h / 0 °C

6: 96 percent / sodium borohydride / ethanol / 1.5 h / -20 °C

7: 95 percent / HCl / acetone / 2 h / 20 °C

8: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

9: toluene / 31 h / 138 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/ol027125o

Reference yield:

: 16271-49-1
(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

: 493021-05-9
acetic acid 3-(tert-butyl-diphenyl-silanyloxymethyl)-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / pyridine; 4-(dimethylamino)pyridine / 0 - 20 °C

2: 85 percent / dimethylsulfoxide / 3 h / 20 °C

3: 95 percent / pTSA / benzene / 5 h / Heating

4: 91 percent / diisobutylaluminum hydride / toluene / 1 h / 0 °C

5: 96 percent / sodium borohydride / ethanol / 1.5 h / -20 °C

6: 95 percent / HCl / acetone / 2 h / 20 °C

7: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

8: toluene / 31 h / 138 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/ol027125o