1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

Base Information

• Chemical Name: 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine
• CAS No.: 619276-91-4
• Molecular Formula: C₃₄H₃₇N₃O₈
• Molecular Weight: 615.683

Synonyms:1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

Chemical Property of 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

Chemical Property:

Purity/Quality:

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Technology Process of 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

There total 6 articles about 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N4-isobutyrylcytosine (619276-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: collodine / CH₂Cl₂ / 12 h / 20 °C

2: 15 g / NaHCO₃; citric acid

With collodine; sodium hydrogencarbonate; citric acid; In dichloromethane;

DOI:10.1002/hlca.200390118

Reference yield:

1-α-L-arabinopyranosylcytosine (55530-11-5) → 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N4-isobutyrylcytosine (619276-91-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 6.4 g / dimethylformamide / 15 h / 20 °C

2: collidine; molecular sieves (4 Angstroem) / dimethylformamide / 3 h / 20 °C

3: collodine / CH₂Cl₂ / 12 h / 20 °C

4: 15 g / NaHCO₃; citric acid

With 2,3,5-trimethyl-pyridine; 4 A molecular sieve; collodine; sodium hydrogencarbonate; citric acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390118

Reference yield:

1-(α-L-arabinopyranosyl)-N4-isobutyrylcytosine (619276-75-4) → 1-{2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N4-isobutyrylcytosine (619276-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1: collidine; molecular sieves (4 Angstroem) / dimethylformamide / 3 h / 20 °C

2: collodine / CH₂Cl₂ / 12 h / 20 °C

3: 15 g / NaHCO₃; citric acid

With 2,3,5-trimethyl-pyridine; 4 A molecular sieve; collodine; sodium hydrogencarbonate; citric acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390118

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-α-L-arabinopyranosylcytosine

1-(α-L-arabinopyranosyl)-N⁴-isobutyrylcytosine

1',2',3',4'-tetra-O-benzoyl-α/β-L-arabinopyranose

Downstream raw materials:

1-{3'-O-benzoyl-2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

1-{4'-O-benzoyl-2'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-arabinopyranosyl}-N⁴-isobutyrylcytosine

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