(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

Base Information

Chemical Name:(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide
CAS No.:1269621-76-2
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

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Chemical Property of (S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

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Technology Process of (S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

There total 5 articles about (S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1269622-30-1
(E)-3-{4-[(S)-2-(1H-indol-3-ylmethyl)-pyrrolidin-1-ylmethyl]-phenyl}-acrylic acid methyl ester

: 1269621-76-2
(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: (E)-3-{4-[(S)-2-(1H-indol-3-ylmethyl)-pyrrolidin-1-ylmethyl]-phenyl}-acrylic acid methyl ester; With hydroxylamine; sodium methylate; In methanol; water; for 0.25h;

With hydrogenchloride; In methanol; water; pH=8;

Reference yield:

: 881650-42-6
(S)-2-(1H-indol-3-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester

: 1269621-76-2
(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium(II) hydroxide / ethanol / 12 h / 760.05 Torr

2.1: tetrahydrofuran / 1 h

2.2: 4 h

3.1: sodium methylate; hydroxylamine / water; methanol / 0.25 h

3.2: pH 8

With hydrogen; hydroxylamine; sodium methylate; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 82354-30-1
benzyl (S)-2-(1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

: 1269621-76-2
(S,E)-3-(4-((2-((1H-indol-3-yl)methyl)pyrrolidin-1-yl)methyl)phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / tetrahydrofuran / 4 h / Reflux; Inert atmosphere

2.1: hydrogen / palladium(II) hydroxide / ethanol / 12 h / 760.05 Torr

3.1: tetrahydrofuran / 1 h

3.2: 4 h

4.1: sodium methylate; hydroxylamine / water; methanol / 0.25 h

4.2: pH 8

With lithium borohydride; hydrogen; hydroxylamine; sodium methylate; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; water;