3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

Base Information

Chemical Name:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide
CAS No.:1454656-31-5
Molecular Formula:C₁₈H₂₃N₅O
Molecular Weight:325.414
Hs Code.:

Synonyms:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

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Chemical Property of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

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Technology Process of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

There total 8 articles about 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1454657-35-2
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid

: 109-73-9,85404-21-3
N-butylamine

: 1454656-31-5
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

Guidance literature:: 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃;

N-butylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16.5h;

Reference yield:

: 1454657-33-0
methyl 3-(3-((dimethylamino)methylene)-4-oxopiperidin-1-yl)benzoate

: 1454656-31-5
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / ethanol / 15 h / Reflux

2.1: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 50 °C

3.2: 16.5 h / 20 °C

With water; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 658689-49-7
methyl-3-(4-oxopiperidin-1-yl)-benzoate

: 1454656-31-5
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-butylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,4-dioxane / 43 h / Reflux

2.1: sodium acetate / ethanol / 15 h / Reflux

3.1: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 50 °C

4.2: 16.5 h / 20 °C

With water; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;