2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

Base Information

Chemical Name:2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid
CAS No.:1414867-49-4
Molecular Formula:C₂₂H₃₁BO₄
Molecular Weight:370.297
Hs Code.:

Synonyms:2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

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Chemical Property of 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

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Technology Process of 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

There total 3 articles about 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1166828-25-6
methyl 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

: 1414867-49-4
2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 120 ℃; for 0.5h;
DOI:10.1021/jm301296t

Reference yield:

: 70631-58-2
methyl 2-(4-phenylbicyclo[2.2.2]octan-1-yl)acetate

: 1414867-49-4
2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: [bis-(trifluoroacetoxy)iodo]benzene; iodine / chloroform / 1.5 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

3: sodium hydroxide / methanol; water / 0.5 h / 120 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis-(trifluoroacetoxy)iodo]benzene; iodine; potassium acetate; sodium hydroxide; In methanol; chloroform; water; dimethyl sulfoxide;
DOI:10.1021/jm301296t

Reference yield:

: 1166828-27-8
methyl 2-(4-(4-iodophenyl)bicyclo[2.2.2]octan-1-yl)acetate

: 1414867-49-4
2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2] octan-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 0.5 h / 120 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydroxide; In methanol; water; dimethyl sulfoxide;
DOI:10.1021/jm301296t