4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

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Chemical Name:4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole
CAS No.:1383575-34-5
Molecular Formula:C₁₆H₂₄BrN₃O₂Si
Molecular Weight:398.375
Hs Code.:

Synonyms:4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

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Chemical Property of 4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

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Technology Process of 4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

There total 5 articles about 4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1383575-33-4
[5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazol-4-yl]-methanol

: 1383575-34-5
4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: (E/Z)-3-(3-methoxy-phenyl)-2-nitro-acrylic acid methyl ester

: 1383575-34-5
4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 16.67 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 3.5 h / 20 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3.2: 2.5 h

4.1: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 20 °C / Inert atmosphere

With carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; acetonitrile; mineral oil;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1383575-34-5
4-Bromomethyl-5-(3-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,3]triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; titanium tetrachloride / tetrachloromethane; tetrahydrofuran / 16.92 h / 0 - 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.2: 16.67 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 3.5 h / 20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4.2: 2.5 h

5.1: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; carbon tetrabromide; tetrabutyl ammonium fluoride; titanium tetrachloride; sodium hydride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; tetrachloromethane; toluene; acetonitrile; mineral oil;