Technology Process of (E)-1-(2-(hexa-3’,5’-dienyloxy)phenyl)-1-(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)ethanol
There total 6 articles about (E)-1-(2-(hexa-3’,5’-dienyloxy)phenyl)-1-(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication
2.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C
4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
4.2: 3 h / -78 °C / Inert atmosphere
5.1: diethyl ether / 16 h / -78 - 20 °C / Inert atmosphere
With
oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
1.1: |Mitsunobu Displacement;
DOI:10.1039/c3cc49526d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 12.25 h / 0 - 20 °C / Inert atmosphere
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication
3.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C
5.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
5.2: 3 h / -78 °C / Inert atmosphere
6.1: diethyl ether / 16 h / -78 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
2.1: |Mitsunobu Displacement;
DOI:10.1039/c3cc49526d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium; diisopropylamine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / diethyl ether / 12.25 h / 0 - 20 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication
4.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C
6.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
6.2: 3 h / -78 °C / Inert atmosphere
7.1: diethyl ether / 16 h / -78 - 20 °C / Inert atmosphere
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
3.1: |Mitsunobu Displacement;
DOI:10.1039/c3cc49526d
