(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

Base Information

Chemical Name:(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol
CAS No.:235792-16-2
Molecular Formula:C₁₀H₁₂O₃
Molecular Weight:180.203
Hs Code.:

Synonyms:(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

Chemical Property:

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Technology Process of (S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

There total 2 articles about (S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 908118-85-4
(S)-(-)-α-ethyl-2-iodo-4,5-methylenedioxybenzyl alcohol

: 638164-11-1
4,4,5,5-tetramethyl-2-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-[1,3,2]dioxaborolane

: 1-[6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxol-5-yl]-propan-1-ol

: C₂₀H₂₄O₇

: 235792-16-2
(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

Guidance literature:: (S)-(-)-α-ethyl-2-iodo-4,5-methylenedioxybenzyl alcohol; 4,4,5,5-tetramethyl-2-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-[1,3,2]dioxaborolane; With barium dihydroxide; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 2.5h; a;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h; Further stages.;
DOI:10.1002/chem.200601764

Reference yield:

: 908118-85-4
(S)-(-)-α-ethyl-2-iodo-4,5-methylenedioxybenzyl alcohol

: 638164-11-1
4,4,5,5-tetramethyl-2-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-[1,3,2]dioxaborolane

: 1-[6-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-benzo[1,3]dioxol-5-yl]-propan-1-ol

: 1-[6-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-benzo[1,3]dioxol-5-yl]-propan-1-ol

: 235792-16-2
(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

Guidance literature:: With barium dihydroxide; DavePhos; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 2.5h; Title compound not separated from byproducts;
DOI:10.1002/anie.200600451

Reference yield:

: 235792-16-2
(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

: 1-[6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxol-5-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 57 percent / I₂; silver trifluoroacetate / CHCl₃ / 0.25 h / 0 °C

2.1: Ba(OH)2*8H₂O; 2-(dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl / Pd(OAc)2 / dioxane; H₂O / 2.5 h / 100 °C

2.2: 42 percent / TBAF / tetrahydrofuran / 0.25 h / 20 °C

With barium dihydroxide; iodine; silver trifluoroacetate; DavePhos; palladium diacetate; In 1,4-dioxane; chloroform; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1002/anie.200600451