2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride

Base Information

Chemical Name:2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
CAS No.:177172-49-5
Molecular Formula:C₁₈H₂₂ClNO*ClH
Molecular Weight:340.293
Hs Code.:
Mol file:177172-49-5.mol

Synonyms:Norcalcin;KRN-568;R-568;Tecalcet hydrochloride;Tecalcet HCl;NPS R-568;

Suppliers and Price of 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
R 568 hydrochloride
10mg
$ 418.00

TRC
R568Hydrochloride
10mg
$ 160.00

Tocris
R568hydrochloride ≥99%(HPLC)
10
$ 166.00

Tocris
R568hydrochloride ≥99%(HPLC)
50
$ 685.00

Crysdot
(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-aminehydrochloride 95%
100mg
$ 405.00

Crysdot
(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-aminehydrochloride 95%
10mg
$ 127.00

ChemScene
Tecalcet(Hydrochloride) 99.66%
5mg
$ 80.00

ChemScene
Tecalcet(Hydrochloride) 99.66%
10mg
$ 130.00

Cayman Chemical
R-568 ≥98%
50mg
$ 580.00

Cayman Chemical
R-568 ≥98%
10mg
$ 131.00

Total 9 raw suppliers

Chemical Property of 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride

Chemical Property:

Vapor Pressure:3.86E-07mmHg at 25°C
Boiling Point:416.3°C at 760 mmHg
Flash Point:205.6°C
PSA：21.26000
LogP:5.82490
Storage Temp.:Desiccate at RT

Purity/Quality:

98%Min ^*data from raw suppliers

R 568 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR.
Uses Treatment of hyperparathyroidism and related disorders, such as hypercalcemia (reduction of PTH secretion through modulation of calcium ion receptors on parathyroid cells). R 568 Hydrochloride is a calcimimetic, which prevents vascular remodeling in uremia.

Technology Process of 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride

There total 6 articles about 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 148717-49-1,148717-54-8
tecalcet

: 177172-49-5
Tecalcet hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 0 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201504052

Reference yield:

: 177172-48-4
(R)-3-(2-chlorophenyl)-N-(1-(3'-methoxyphenyl)ethyl)propanamide

: 177172-49-5
Tecalcet hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 189289-49-4
[3-(2-Chloro-phenyl)-propyl]-[1-(3-methoxy-phenyl)-eth-(E)-ylidene]-amine

: 177172-49-5
Tecalcet hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: (R)-3,3'-bis[4-methyl-3,5-dinitrophenyl]-1,1'-binaphthyl-2,2'-disulfonimide; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate / 1,3,5-trimethyl-benzene / 120 h / 10 °C / Inert atmosphere

2: hydrogenchloride / 1,3,5-trimethyl-benzene; 1,4-dioxane / 4 h / 50 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / 0 °C / Inert atmosphere

With hydrogenchloride; (R)-3,3'-bis[4-methyl-3,5-dinitrophenyl]-1,1'-binaphthyl-2,2'-disulfonimide; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In 1,4-dioxane; diethyl ether; 1,3,5-trimethyl-benzene;
DOI:10.1002/anie.201504052