9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

Base Information

Chemical Name:9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
CAS No.:67441-26-3
Molecular Formula:C33H39NO13
Molecular Weight:657.66
Hs Code.:
DSSTox Substance ID:DTXSID20986716

9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

Synonyms:MAR 70;MAR-70;MAR70

Suppliers and Price of 9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

Chemical Property:

Vapor Pressure:8.73E-32mmHg at 25°C
Boiling Point:863.3°C at 760 mmHg
Flash Point:475.9°C
PSA：224.53000
Density:1.53g/cm³
LogP:1.61020
XLogP3:1.7
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:6
Exact Mass:657.24214030
Heavy Atom Count:47
Complexity:1200

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(CC(O1)OC2C(OC(CC2N)OC3CC(CC4=C3C(=C5C(=C4O)C(=O)C6=C(C5=O)C(=CC=C6)OC)O)(C(=O)C)O)C)O)O

Technology Process of 9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

There total 19 articles about 9-acetyl-7-[4-amino-5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81661-55-4
7-O-<4-O-(3,4-di-O-acetyl-2,6-didesoxy-α-L-lyxo-hexopyranosyl)-2,3,6-tridesoxy-3-(trifluoroacetamido)-α-L-lyxo-hexopyranosyl>daunomycinone

: 81703-98-2,67441-26-3
7-<3-amino-2,3,6-trideoxy-4-O-(2,6-dideoxy-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl>daunomycinone

Guidance literature:: With sodium hydroxide; In various solvent(s); at 0 ℃; for 7h;
DOI:10.1016/S0008-6215(00)80810-1

Reference yield: 89.0%

: 82225-08-9
7-O-<4-O-(2,6-didesoxy-α-L-lyxo-hexopyranosyl)-2,3,6-tridesoxy-3-(trifluoroacetamido)-α-L-lyxo-hexopyranosyl>daunomycinone

: 81703-98-2,67441-26-3
7-<3-amino-2,3,6-trideoxy-4-O-(2,6-dideoxy-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl>daunomycinone

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 5h;
DOI:10.1016/0040-4020(81)85015-6

Reference yield:

: 64605-19-2
3,4-di-O-acetyl-2,6-dideoxy-α-L-lyxo-hexopyranosyl chloride

: 81703-98-2,67441-26-3
7-<3-amino-2,3,6-trideoxy-4-O-(2,6-dideoxy-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl>daunomycinone

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / mercuric bromide, yellow mecuric oxide / 30 h

2: 78 percent / hydrogen / 10percent palladium-on-charcoal / ethanol

3: 100 percent / pyridine / 0 °C

4: 57 percent / tin tetrachloride / CH₂Cl₂ / 0.75 h / Ambient temperature

5: 100 percent / 0.1M NaOH / various solvent(s) / 7 h / 0 °C

With pyridine; sodium hydroxide; hydrogen; tin(IV) chloride; mercury dibromide; mercury(II) oxide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0008-6215(00)80810-1