1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

Base Information

Chemical Name:1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one
CAS No.:1069047-66-0
Molecular Formula:C₂₆H₂₂F₃NO
Molecular Weight:421.462
Hs Code.:

Synonyms:1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

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Chemical Property of 1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

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Technology Process of 1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

There total 11 articles about 1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1069045-83-5
3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid

: 407-25-0
trifluoroacetic anhydride

: 1069047-66-0
1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

Guidance literature:: 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 1h;

trifluoroacetic anhydride; With pyridine; In toluene; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: C₂₅H₂₂ClNO

: 407-25-0
trifluoroacetic anhydride

: 1069047-66-0
1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

Guidance literature:: With pyridine; In toluene; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/jm500494y

Reference yield:

: 1069046-12-3
5-bromo-1-phenyl-3-phenylacetyl-1H-indole

: 1069047-66-0
1,1,1-trifluoro-4-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]butan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: tin(IV) chloride; triethylsilane / dichloromethane / 1 h / -78 °C

3.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube

4.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating

4.2: pH 1

5.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

6.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

7.1: pyridine / toluene / 2 h / 20 °C / Cooling with ice

With pyridine; triethylsilane; sodium tetrahydroborate; oxalyl dichloride; palladium on activated charcoal; hydrogen; palladium diacetate; tin(IV) chloride; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Heck Reaction;
DOI:10.1021/jm500494y