2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Base Information

• Chemical Name: 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine
• CAS No.: 83099-97-2
• Molecular Formula: C₂₇H₃₆N₄O₂
• Molecular Weight: 448.608

Synonyms:2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Chemical Property of 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Chemical Property:

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Technology Process of 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

There total 2 articles about 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(2-chloropropionyl)-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83099-96-1) + 1-(2-ethoxyphenyl)piperazine monohydrochloride (83081-75-8) → 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83099-97-2)

Guidance literature:

With triethylamine; In ethanol; for 76h; Heating;

DOI:10.1248/cpb.32.3981

Reference yield:

1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]-naphthyridine (83137-21-7) → 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83099-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

2: 84 percent / Et₃N / ethanol / 76 h / Heating

With triethylamine; In ethanol; chloroform;

DOI:10.1248/cpb.32.3981

Reference yield:

DL-tartaric acid (133-37-9,138508-61-9) + 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propionyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83099-97-2) → 2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine ditartrate (83081-76-9)

Guidance literature:

With lithium aluminium tetrahydride; 1.) ether, 4 h, reflux; 2.) acetone;

DOI:10.1248/cpb.32.3981

upstream raw materials:

2-(2-chloropropionyl)-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

1-(2-ethoxyphenyl)piperazine monohydrochloride

1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]-naphthyridine

Downstream raw materials:

2-<2-<4-(2-ethoxyphenyl)-1-piperazinyl>propyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine ditartrate

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