N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine

Base Information

• Chemical Name: N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine
• CAS No.: 109890-53-1
• Molecular Formula: C₁₅H₁₁F₃N₄OS
• Molecular Weight: 352.34
• Mol file: 109890-53-1.mol

Synonyms:N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine

Chemical Property of N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine

There total 4 articles about N⁴-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methylthio-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine (109890-47-3) → N4-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine (109890-53-1)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 27h; Ambient temperature;

DOI:10.1021/jm00394a038

Reference yield:

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4(3H)-quinazolinone (109890-44-0) → N4-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine (109890-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / P₂S₅ / pyridine / 22 h / 80 °C

2: 53 percent / dimethylformamide / 1 h / Ambient temperature

3: 92 percent / hydroxylamine hydrochloride, pyridine / 27 h / Ambient temperature

With pyridine; tetraphosphorus decasulfide; hydroxylamine hydrochloride; In pyridine; N,N-dimethyl-formamide;

DOI:10.1021/jm00394a038

Reference yield:

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4-quinazolinethiol (109890-45-1) → N4-hydroxy-6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine (109890-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / dimethylformamide / 1 h / Ambient temperature

2: 92 percent / hydroxylamine hydrochloride, pyridine / 27 h / Ambient temperature

With pyridine; hydroxylamine hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00394a038

upstream raw materials:

4-methylthio-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4-quinazolinethiol

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4(3H)-quinazolinone

6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine