(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

Base Information

Chemical Name:(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid
CAS No.:370104-34-0
Molecular Formula:C₂₆H₂₁NO₆
Molecular Weight:443.456
Hs Code.:

Synonyms:(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

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Chemical Property of (2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

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Technology Process of (2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

There total 8 articles about (2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223438-52-6
benzyl 1H-indole-6-carboxylate

: 370104-34-0
(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0 °C

2: dimethylformamide / 4 h / 90 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1007/s00044-004-0021-y

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 370104-34-0
(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 20 °C

2: NaH / tetrahydrofuran / 0 °C

3: dimethylformamide / 4 h / 90 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-004-0021-y

Reference yield:

: 27738-46-1
3,4-(methylenedioxy)mandelic acid

: 370104-34-0
(2S)-1,3-benzodioxol-5-yl{6-[(benzyloxy)carbonyl]-1-methyl-1H-indol-3-yl}ethanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / water; dichloromethane; toluene / 4 h / 20 °C

2: N,N-dimethyl-formamide / 4 h / 90 °C

3: ethyl acetate

4: hydrogenchloride; (R)-1-phenyl-ethyl-amine / water; ethyl acetate

With hydrogenchloride; (R)-1-phenyl-ethyl-amine; hydrogen bromide; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op050102f