4-methoxy-3-(2-propynyloxy)benzaldehyde

Base Information Edit

Chemical Name:4-methoxy-3-(2-propynyloxy)benzaldehyde
CAS No.:145654-02-0
Molecular Formula:C₁₅H₂₀O₄
Molecular Weight:264.321
Hs Code.:
Mol file:145654-02-0.mol

Synonyms:4-methoxy-3-(2-propynyloxy)benzaldehyde

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Chemical Property of 4-methoxy-3-(2-propynyloxy)benzaldehyde Edit

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Technology Process of 4-methoxy-3-(2-propynyloxy)benzaldehyde

There total 2 articles about 4-methoxy-3-(2-propynyloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 145654-01-9
4-methoxy-3-(prop-2-yn-1-yloxy)benzaldehyde

: 122-51-0
orthoformic acid triethyl ester

: 145654-02-0
4-methoxy-3-(2-propynyloxy)benzaldehyde

Guidance literature:: With ammonium chloride; In ethanol; for 3h; Heating;
DOI:10.1248/cpb.40.2002

Reference yield:

: 621-59-0
isovanillin

: 145654-02-0
4-methoxy-3-(2-propynyloxy)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 4 h / Ambient temperature

2: 91 percent / NH₄Cl / ethanol / 3 h / Heating

With potassium carbonate; ammonium chloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.2002

Reference yield:

: 145654-02-0
4-methoxy-3-(2-propynyloxy)benzaldehyde

: 3895-92-9
chelerythrine chloride

Guidance literature:: Multi-step reaction with 13 steps

1: 70 percent / CsF, N,N-diethylaniline / 3 h / Heating

2: 94 percent / 10percent NaOH / ethanol / Ambient temperature

3: 87 percent / acetic acid / 2-ethoxy-ethanol; H₂O / 0.08 h / 110 - 120 °C

4: 91 percent / NaOH / H₂O; ethanol / 4 h / Heating

5: 94 percent / H₂, 1percent aq.PdCl₂, Norit / acetic acid / 760 Torr / Ambient temperature

6: 86 percent / POCl₃, K₂CO₃ / acetonitrile / 2.5 h / 55 - 60 °C

7: 1.) TiCl₄, 2.) NaBH₄ / 1.) CHCl₃, a) RT, 2.5 h, b) reflux, 30 min, 2.) MeOH, RT, overnight

8: 91 percent / CHCl₃ / 3 h / Heating

9: 89 percent / DDQ / benzene / 2 h / Heating

10: 77 percent / OsO₄, pyridine / 2 h / Ambient temperature

11: 70 percent / HIO₄*2H₂O / H₂O; dioxane / 2 h / Ambient temperature

12: 92 percent / K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

13: 49 percent / 1.) p-toluenesulfonic acid, 2.) aq. 10percent HCl / xylene / 7.5 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; hydrogen; titanium tetrachloride; potassium carbonate; pyrographite; toluene-4-sulfonic acid; acetic acid; periodic acid; cesium fluoride; N,N-diethylaniline; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dichloride; trichlorophosphate; In 1,4-dioxane; 2-ethoxy-ethanol; ethanol; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; xylene; benzene;
DOI:10.1248/cpb.40.2002