N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Base Information

Chemical Name:N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
CAS No.:1589602-06-1
Molecular Formula:C₂₄H₂₀F₄N₂O
Molecular Weight:428.429
Hs Code.:

Synonyms:N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Chemical Property:

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Technology Process of N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

There total 7 articles about N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1589601-97-7
1-methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 1195-45-5
para-fluorophenyl isocyanate

: 1589602-06-1
N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm401955h

Reference yield:

: 64-04-0
phenethylamine

: 1589602-06-1
N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: phosphorus pentoxide / 165 °C

3: acetonitrile / 4 h / Reflux

4: tetrahydrofuran; diethyl ether / 16 h / 20 °C

5: palladium 10% on activated carbon; hydrogen; acetic acid / 16 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With phosphorus pentoxide; palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/jm401955h

Reference yield:

: 1159997-91-7
1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline

: 1589602-06-1
N-(4-fluorophenyl)-1-methyl-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 4 h / Reflux

2: tetrahydrofuran; diethyl ether / 16 h / 20 °C

3: palladium 10% on activated carbon; hydrogen; acetic acid / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm401955h