4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

Base Information

• Chemical Name: 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide
• CAS No.: 1489248-22-7
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 1489248-22-7.mol

Synonyms:4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

Chemical Property of 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

There total 3 articles about 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(3-methoxybenzoyl)-N-pyrrolidin-1-yl-benzamide (1489248-16-9) → 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide (1489248-22-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.09.014

Reference yield:

4-(3-Methoxy-benzoyl)-benzoyl chloride (1027905-05-0) → 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide (1489248-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 20 °C

2: sodium tetrahydroborate / ethanol; water / 2 h / 20 °C

With sodium tetrahydroborate; In ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.09.014

Reference yield:

4-(3-methoxybenzoyl)benzoic acid (156727-76-3) → 4-[hydroxy-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide (1489248-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 3 h / 110 °C / Inert atmosphere

2: dichloromethane / 4 h / 20 °C

3: sodium tetrahydroborate / ethanol; water / 2 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol; dichloromethane; water; toluene;

DOI:10.1016/j.ejmech.2013.09.014

upstream raw materials:

4-(3-Methoxy-benzoyl)-benzoyl chloride

4-(3-methoxybenzoyl)-N-pyrrolidin-1-yl-benzamide

4-(3-methoxybenzoyl)benzoic acid

Downstream raw materials:

4-[(10-allyl-9,10-diazatricyclo[4.2.1.1^2,5]dec-9-yl)-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

4-[(10-allyl-9,10-diazatricyclo[4.2.1.1^2,5]dec-9-yl)-(3-hydroxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

4-[chloro-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide

4-[(10-benzyl-9,10-diazatricyclo[4.2.1.1^2,5]dec-9-yl)-(3-methoxyphenyl)methyl]-N-pyrrolidin-1-yl-benzamide