Technology Process of 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile
There total 13 articles about 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.42 h / 125 °C / microwave reactor
3.1: hydrazine / ethanol / 3 h / Rerflux
4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C
4.2: 20 °C
With
dmap; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; hydrazine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetic acid; 4-{[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]oxy}benzohydrazide;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
With
Burgess Reagent;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N,N-dimethyl-formamide / 0 °C
1.2: Cooling with ice
2.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere
2.2: Cooling with ice
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
4.2: 4 h / 0 - 20 °C
4.3: 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C
5.2: 0 °C
6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C
7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C
8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
9.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C
9.2: 20 °C
With
2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; lithium iodide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
