diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

Base Information

Chemical Name:diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate
CAS No.:960506-47-2
Molecular Formula:C₂₀H₃₇O₇PSSi
Molecular Weight:480.635
Hs Code.:

Synonyms:diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

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Chemical Property of diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

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Technology Process of diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

There total 5 articles about diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 960506-46-1
diethyl [(2-hydroxymethyl)-3-methoxybenzylsulfonyl]methylphosphonate

: 69739-34-0
t-butyldimethylsiyl triflate

: 960506-47-2
diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 - 20 ℃; for 1h;
DOI:10.1016/j.tet.2007.09.057

Reference yield:

: 857652-04-1
2-(bromomethyl)-6-methoxybenzyl alcohol

: 960506-47-2
diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / potassium carbonate / ethanol / 24 h / 0 °C

2: 79 percent / sodium hydrogen carbonate; m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / 0 °C

3: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 - 20 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2007.09.057

Reference yield:

: 960506-52-9
C₁₄H₂₃SPO₅

: 960506-47-2
diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / sodium hydrogen carbonate; m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / 0 °C

2: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 - 20 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/j.tet.2007.09.057