(Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide

Base Information

• Chemical Name: (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide
• CAS No.: 124827-15-2
• Molecular Formula: C₂₅H₂₅N₃O₂
• Molecular Weight: 399.492
• Mol file: 124827-15-2.mol

Synonyms:(Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide

Chemical Property of (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide

There total 3 articles about (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzylpenicillin potassium salt (113-98-4,21794-94-5,68244-03-1) + p-toluidine (106-49-0,12221-03-3) → 3,3-dimethyl-D-cysteine (52-67-5) + (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide (124827-15-2)

Guidance literature:

With acetic acid; In water; toluene; for 5h; Ambient temperature; Heating;

DOI:10.1248/cpb.37.1609

Reference yield:

(Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide (124827-15-2) → (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide (124827-15-2)

Guidance literature:

With silica gel; In methanol; for 15h; Heating;

DOI:10.1248/cpb.37.1609

Reference yield:

benzylpenicillin potassium salt (113-98-4,21794-94-5,68244-03-1) → (Z)-N-(p-methylphenyl)-3-(p-methylanilino)-2-(2-phenylacetamido)acrylamide (124827-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / acetic acid / H₂O; toluene / 5 h / Ambient temperature; Heating

2: silica gel / methanol / 15 h / Heating

With silica gel; acetic acid; In methanol; water; toluene;

DOI:10.1248/cpb.37.1609

upstream raw materials:

benzylpenicillin potassium salt

p-toluidine