7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1446946-28-6
Molecular Formula:C₂₈H₃₁FN₄O₇
Molecular Weight:554.575
Hs Code.:

Synonyms:7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 8 articles about 7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 139693-52-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate

: 3-amino-4-(3',4'-dimethoxylbenzyloxyimino)piperidine dihydrochloride

: 1446946-28-6
7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate; 3-amino-4-(3',4'-dimethoxylbenzyloxyimino)piperidine dihydrochloride; With triethylamine; In acetonitrile; at 20 - 50 ℃;

With sodium hydroxide; In acetonitrile; at 50 ℃; for 1h;
DOI:10.3390/molecules18043872

Reference yield:

: 1446946-02-6
C₂₀H₂₉N₃O₆

: 1446946-28-6
7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hypobromide / acetonitrile / 11 h / 5 - 20 °C

2.1: hydrogenchloride / dichloromethane / 1.5 h / 20 °C

3.1: triethylamine / acetonitrile / 20 - 50 °C

3.2: 1 h / 50 °C

With hydrogenchloride; sodium hypobromide; triethylamine; In dichloromethane; acetonitrile; 1.1: |Hofmann Rearrangement;
DOI:10.3390/molecules18043872

Reference yield:

: 1446946-15-1
C₁₉H₂₉N₃O₅

: 1446946-28-6
7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane / 1.5 h / 20 °C

2.1: triethylamine / acetonitrile / 20 - 50 °C

2.2: 1 h / 50 °C

With hydrogenchloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.3390/molecules18043872