N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

Base Information

Chemical Name:N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol
CAS No.:355127-52-5
Molecular Formula:C₄₀H₄₃NO₂SSi
Molecular Weight:629.938
Hs Code.:

Synonyms:N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

Chemical Property:

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Technology Process of N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

There total 1 articles about N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 355127-52-5
N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / triethylamine / toluene / 3 h

2: 88 percent / N-hydroxybenzotriazole; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1016/S0968-0896(00)00339-4

Reference yield: 78.0%

: 355127-52-5
N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

: 355127-53-6
N-(S-trityl-2-mercaptoacetyl)-3-aminopropanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1016/S0968-0896(00)00339-4

Reference yield:

: 355127-52-5
N-(S-trityl-2-mercaptoacetyl)-O-tert-butyldiphenylsilyl-3-aminopropanol

: O-(N-(S-trityl-2-mercaptoacetyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

2: 55 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(00)00339-4