(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Base Information

Chemical Name:(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate
CAS No.:476689-74-4
Molecular Formula:C₂₇H₂₉ClN₂O₅
Molecular Weight:496.991
Hs Code.:

Synonyms:(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

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Chemical Property of (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

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Technology Process of (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

There total 9 articles about (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 252349-43-2
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-2-(5-chloro-2-iodoanilino)-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)butanoate

: (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4S)-7-chloro-4-(2-oxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

: 476689-74-4
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Guidance literature:: With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 3.5h;
DOI:10.1021/jo020327d

Reference yield: 85.0%

: 252349-43-2
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-2-(5-chloro-2-iodoanilino)-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)butanoate

: 476689-74-4
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; Heating;
DOI:10.1021/op9001824

Reference yield:

: 68166-83-6
D-lactic acid t-butyl ester

: 476689-74-4
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: 100 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 100 percent / toluene / 2 h / Heating

4.1: TiCl₄ / CH₂Cl₂; toluene / 0.33 h / -78 °C

4.2: 77 percent / CH₂Cl₂; toluene / 0.25 h / -78 °C

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: 55 percent / PPh₃ / CH₂Cl₂ / 2 h

6.1: 70 percent / DBU / acetonitrile / 3 h / -20 °C

7.1: 85 percent / Et₃N / Pd(PPh₃)4 / toluene / 3.5 h / 110 °C

With dmap; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo020327d